The care and management of bisphosphonate--associated osteonecrosis of the jaw in the patient with multiple myeloma: a case study.
نویسندگان
چکیده
PURPOSE This is a case study of a patient with multiple myeloma presenting with bisphosphonate-associated osteonecrosis of the jaw after an extraction of tooth #18 while receiving intravenous bisphosphonates. The class of drugs known as bisphosphonates is discussed. The patient's presenting signs and symptoms are reviewed. Bisphosphonate induced osteonecrosis definition, management and professional education are reviewed.
منابع مشابه
Necrotizing fasciitis as a rare complication of osteonecrosis of the jaw in a patient with multiple myeloma treated with lenalidomide: case report and review of the literature
Bisphosphonates (BPs), potent inhibitors of osteoclast-mediated bone resorption, play a major role in the management of patients with multiple myeloma (MM). However, in the case of dental infections, they can lead to bisphosphonate related osteonecrosis of the jaw (BRONJ). This process can be worsened by concomitant antineoplastic therapy. Herein, we present a case of a life-threatening necroti...
متن کاملOral osteonecrosis associated with the use of zoledronic acid: first case of a patient with advanced pancreatic cancer and bone metastases.
while traditionally associated with radiation therapy for head and neck cancer, osteonecrosis of the jaw has recently been described mainly in breast cancer and multiple myeloma patients undergoing long-term intravenous bisphosphonate treatment [1, 2, 3, 4, 5, 6, 7, 8, 9, 10,11, 12, 13, 14, 15]. Bisphosphonates are used to treat bone metastases, as they decrease bone resorption, primarily throu...
متن کاملAvascular mandibular osteonecrosis in association with bisphosphonate therapy: a report on four patients.
UNLABELLED Over the past three years, several reports have been published on jaw osteonecrosis possibly being associated with the administration of bisphosphonates. Bisphosphonates are highly active inhibitors of osteoclasts. These drugs are used for the treatment of multiple myeloma, bone resorption in the case of metastatic malignant diseases, tumor-associated hypercalcaemia, and in the treat...
متن کاملCYP2C8 gene polymorphism and bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma.
Osteonecrosis of the jaw is an uncommon but potentially serious complication of bisphosphonate therapy in multiple myeloma. Previous studies showed that the presence of one or two minor alleles of the cytochrome P450, subfamily 2C polypeptide 8 gene (CYP2C8) polymorphism rs1934951 was an independent prognostic marker associated with development of osteonecrosis of the jaw in multiple myeloma pa...
متن کاملExposed necrotic bone in 183 patients with bisphosphonate-related osteonecrosis of the jaw: Associated clinical characteristics
BACKGROUND The main objective of our study was to identify oral symptoms and signs most likely to be associated with the exposure of necrotic bone in bisphosphonate-related osteonecrosis of the jaw (BRONJ). MATERIAL AND METHODS The study group consisted of 183 patients with BRONJ. We recorded data on the underlying disease, bisphosphonate used, location of osteonecrosis, symptoms, pain, fistu...
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ورودعنوان ژورنال:
- Journal of dental hygiene : JDH
دوره 87 4 شماره
صفحات -
تاریخ انتشار 2013